Bioactive Small Molecules
Cayman Chemical SR 12343, Purity: ≥98%, CAS: 2055101-86-3, 10 mg
An IKKβ NBD mimetic; inhibits the protein-protein interaction between NEMO/IKKγ and IKKβ; selectively disrupts the association of NEMO/IKKγ with IKKβ over TRAF2, IκBα, and IKKα in co-immunoprecipitation assays using RAW 264.7 cells at 25-150 µM; inhibits TNF-α-induced NF-κB activation in a reporter assay; reduces increased serum IL-6 levels in a mouse model of LPS-induced endotoxemia at 10 mg/kg; improves grip strength and reduces muscle fibrosis in the mdx mouse model of Duchenne muscular dystrophy at 30 mg/kg
Medchemexpress LLC MIA Human N-His 10ug
MIA Protein, Human (His) is a recombinant form of human Melanoma Inhibitory Activity (MIA) expressed in Escherichia coli and supplied with a His tag. It is intended for research applications to investigate MIA's effects on melanoma cell growth and its protein-protein interactions in biochemical and cellular assays. The product corresponds to UniProt Q16674 (residues G25-Q131) and is provided at research-scale quantities suitable for assay development.
- Recombinant human MIA expressed in Escherichia coli.
- C-6*His tag for purification and detection.
- Corresponds to residues G25-Q131 of UniProt Q16674.
- Predicted molecular mass ~13.3 kDa (≈14 kDa by SDS-PAGE).
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Low endotoxin level (<1 EU/μg) suitable for cell-based assays.
- Supplied in research-scale quantities for biochemical assays.
Medchemexpress LLC TCO-PEG-TCO | 00-00-0 | 97.1% | 5000 (average) | 5 MG
TCO-PEG-TCO (MW 5000) is a PEG-based bifunctional linker bearing trans-cyclooctene (TCO) end groups for bioorthogonal click chemistry. It is designed to undergo rapid inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine-functionalized partners, making it suitable for PROTAC assembly, bioconjugation, and other applications requiring a flexible, hydrophilic spacer.
- Average molecular weight approximately 5000.
- High purity (97.1%).
- White to off-white solid form.
- Available in small laboratory quantities starting at 5 mg.
- Stable as powder at -20°C for up to 3 years.
- Compatible with tetrazine-based iEDDA click reactions.
- Provides PEG-linked flexibility and improved solubility for conjugates.
Cayman Chemical 2-methyl-α-Ethylaminobutiophenone (hydrochloride), Purity: ≥98%, CAS: 18267-89-5, 5 mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Medchemexpress LLC Tetrapeptide-1 | 1632354-04-1 | 98.41% | 428.52 | 5 MG
Tetrapeptide-1 is a signaling peptide with antioxidant properties. It can stimulate the synthesis of extracellular matrices such as collagen, elastin, and fibronectin, thereby helping to combat signs of skin aging like wrinkles and sagging. It is suitable for use as a cosmetic ingredient.
- Signaling peptide with antioxidant properties
- Stimulates synthesis of extracellular matrices like collagen and elastin
- Helps combat signs of skin aging
- Suitable for use as a cosmetic ingredient
![Medchemexpress LLC [D-Leu-4]-OB3 | 289056-32-2 | 98.9% | 734.82 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000399306.png-250.jpg)
Medchemexpress LLC [D-Leu-4]-OB3 | 289056-32-2 | 98.9% | 734.82 | 10 MG
[D-Leu-4]-OB3 inhibits expressions of pro-inflammatory, proliferative and metastatic genes and PD-L1 expression. It also stimulates the expression of pro-apoptotic genes.
- Inhibits expressions of pro-inflammatory genes
- Inhibits expressions of proliferative genes
- Inhibits expressions of metastatic genes
- Inhibits PD-L1 expression
- Stimulates expression of pro-apoptotic genes
Medchemexpress LLC 3-(S)-(1-Carbamoyl-1,1-diphenylmethyl)pyrrolidine tartrate | 134002-26-9 | 99.9% | 430.45 | 5 G
3-(S)-(1-Carbamoyl-1,1-diphenylmethyl)pyrrolidine tartrate is a valuable drug intermediate utilized in the synthesis of various active compounds. It serves as a foundational building block for pharmaceutical research and development, enabling the creation of new chemical entities.
- Serves as a drug intermediate.
- Applicable for the synthesis of various active compounds.
- Supports pharmaceutical research and development.
Medchemexpress LLC HY-100753 5mg Medchemexpress, STAT3-IN-1 CAS:2059952-75-7 Purity:>98%
Medchemexpress, HY-100753 5mg STAT3-IN-1 CAS:2059952-75-7 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Alvimopan monohydrate | 1383577-62-5 | 99.2% | C25H34N2O5 | 2 MG
Alvimopan monohydrate is a potent, selective, orally active, and reversible μ-opioid receptor antagonist with an IC50 of 1.7 nM. It demonstrates selectivity for the μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors. It is used for the research of postoperative ileus. The salt form usually boasts enhanced water solubility and stability.
- Potent, selective, orally active, and reversible μ-opioid receptor antagonist.
- IC50 of 1.7 nM for μ-opioid receptor.
- Shows selectivity for μ-opioid receptor over κ- and δ-opioid receptors.
- Used for research of postoperative ileus.
- Salt form offers enhanced water solubility and stability.
Cayman Chemical Ceramide Phosphoethanolamine (bovine), Purity: ≥98%, 5 mg
A mixture of ceramide phosphoethanolamines; produced and used by invertebrates such as Drosophila, which lacks sphingomyelin and produced only in very small amounts in mammals; has a role in glial ensheathment of axons in Drosophila; depletion in vitro in mammalian cells leads to ER accumulation of ceramides and apoptosis but ceramide levels are not altered in transgenic mice lacking its biosynthetic enzymes
Cayman Chemical 25I-NBOH (hydrochloride), Purity: ≥95%, CAS: 1539266-12-0, 5 mg
A derivative of 2C-I that acts as a potent agonist for the human serotonin 5-HT2A receptor (Ki = 0.061 nM); intended for research and forensic applications
Apexbio Technology LLC THZ531, 5mg. Cas: 1702809-17-3 MFCD: MFCD31563595. CDK12 and CDK13 covalent inhibitor
HZ531,5mg,Covalent inhibitor, CDK12 and CDK13
Medchemexpress LLC Jnj-8003 | 3118087-68-3 | 99.8% | 576.51 | 1 ML
JNJ-8003 is a potent and orally active non-nucleoside RSV polymerase inhibitor. It targets the L protein polymerase complex of RSV, blocking the transcription and replication of the viral genome by inhibiting RNA-dependent RNA polymerase (RdRp) activity. It demonstrates subnanomolar activity in vitro and prominent efficacy in mice and neonatal lamb models, making it suitable for respiratory syncytial virus (RSV) research.
- Potent and orally active non-nucleoside RSV polymerase inhibitor
- Targets the L protein polymerase complex of RSV
- Blocks transcription and replication of viral genome
- Inhibits RNA-dependent RNA polymerase (RdRp) activity
- Displays subnanomolar activity in vitro
- Prominent efficacy in mice and neonatal lamb models
- Used for the study of respiratory syncytial virus (RSV)
![Medchemexpress LLC 4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid | 215307-86-1 | MFCD18384955 | 98.9% | 351.40 g·mol⁻¹ | C21H21NO4 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000240882.png-250.jpg)
Medchemexpress LLC 4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid | 215307-86-1 | MFCD18384955 | 98.9% | 351.40 g·mol⁻¹ | C21H21NO4 | 100 MG
BMS 753 is a research-grade, isotype-selective retinoic acid receptor α (RARα) agonist reported to have a Ki of 2 nM. It is supplied as a solid research chemical with documented solubility and storage recommendations for in vitro and in vivo use.
- Potent RARα agonist with reported Ki = 2 nM.
- High purity, reported ~98.9% by HPLC.
- Molecular weight 351.40 g·mol⁻¹; formula C21H21NO4.
- Soluble in DMSO for in vitro use (50 mg/mL) with recommended vehicle protocols for in vivo dosing.
- Powder stability: -20°C recommended for long-term storage.
- Supplied in multiple pack sizes suitable for assay development and preclinical studies.